Management Team

Arthur Tzianabos, Ph.D., President and Chief Executive Officer

Arthur TzianabosArthur Tzianabos brings 25 years of experience in the biotechnology industry leading teams in the discovery, development, clinical translation and commercialization of new treatments for rare diseases. During his nine-year tenure at Shire, he played an active role in the development, approval, and commercial launch of multiple therapies for patients with rare genetic disorders. He also worked closely with the Business Development and Corporate Venture functions to invest in and acquire new companies and technologies to build Shire’s product pipeline. Dr. Tzianabos joins Homology Medicines from OvaScience where he served as President and CSO and was responsible for translating breakthrough science into new treatments, which included the commercial launch of the company’s first product. Earlier in his career, Dr. Tzianabos was an Associate Professor of Medicine at Harvard Medical School and maintained laboratories at the Channing Laboratory, Brigham and Women’s Hospital and the Department of Microbiology and Molecular Genetics at Harvard Medical School. He has published more than 80 scientific papers, reviews, book chapters, and patents. Dr. Tzianabos holds a B.S. in Biology from Boston College and a Ph.D. in Microbiology from the University of New Hampshire.

Sam Rasty, Ph.D., Chief Operating Officer

Sam RastySam Rasty brings together more than 20 years of scientific, clinical, commercial, strategy and business development experience in the life sciences sector across multiple specialty therapeutic areas, rare diseases and technology platforms, spanning from start-up biotechnology to global large pharmaceutical companies. Most recently he was Vice President and Head of New Products at the Rare Diseases Business Unit of Shire Pharmaceuticals. In this role, he was positioned at the intersection of Commercial, R&D and Business Development to drive the strategy for growth of the rare disease business through internal product development and external licensing and acquisitions. Prior to joining Shire, Dr. Rasty’s responsibilities included Corporate Development and Strategic Marketing at Endo Pharmaceuticals as part of the team that drove diversification of Endo’s business through a series of licensing and M&A transactions, and Global Commercial Strategy and Portfolio Management at GlaxoSmithKline within the global R&D organization. Earlier in his career, he held various roles of increasing responsibility in business development and R&D at small, private biotechnology companies. Dr. Rasty holds a Ph.D. in Biochemistry from Louisiana State University, completed his postdoctoral training in Molecular Genetics/Gene Therapy at the University of Pittsburgh School of Medicine and received an M.B.A. from Villanova University.

Albert Seymour, Ph.D., Chief Scientific Officer

Albert SeymourAlbert Seymour has spent more than 20 years coupling the discipline of Human Genetics with Pharmaceutical R&D resulting in the delivery of multiple therapeutic programs into development. Most recently he was the Senior Vice President and Global Head of Research and Nonclinical Development at Shire Pharmaceuticals where he led a team responsible for the delivery of a sustained flow of rare disease therapeutics from idea to IND and supported the full R&D portfolio in the areas of toxicology, bioanalytics, and Drug Metabolism and Pharmacokinetics. Prior to his role as Global Head of Research and Nonclinical Development, Dr. Seymour served as the VP and Head of Drug Discovery and Translational Research at Shire where he doubled the rare disease discovery portfolio in three years. Subsequent to joining Shire, he spent 14 years at Pfizer leading a team in the application of human genetics and computational biology to discover and develop therapeutics and pharmacogenomics strategies in diabetes, inflammatory diseases, and oncology. Dr. Seymour received his undergraduate degree in Biology from the University of Delaware and M.S. degree in Molecular Biology from Johns Hopkins University where he focused on the molecular genetics of cancer. He received his Ph.D. and post-doctoral training in Human Genetics at the University of Pittsburgh.

Brad Smith, Chief Financial Officer

Albert SeymourBrad Smith has more than 27 years of experience leading business and financial operations for public and private companies in the biotechnology and healthcare industry. During his career, he has been instrumental in raising more than $450 million in private and public equity and debt financing, has played a key role in business development and strategic planning functions and has successfully guided three companies through the initial public offering process. Prior to joining Homology, Mr. Smith served as Chief Financial Officer of Ocular Therapeutix, Inc., where he led the company's strategic financings, including an initial public offering and subsequent follow-on offerings, and completed a development and commercialization deal with a major biopharmaceutical company. Previously, Mr. Smith served as CFO of five other companies, including OmniGuide Surgical, NeuroMetrix, Inc., SYNARC, PatientKeeper, Inc. and Focal, Inc. Mr. Smith holds a B.S. in Biology from Tufts University and an M.B.A. from the Whittemore School at the University of New Hampshire, and he became a Certified Public Accountant while working at Coopers & Lybrand.

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