Downstream Process Development Scientist

The successful candidate will be an integral part of a fast paced and rapidly growing group of scientists and engineers developing purification processes for the manufacture of Homology’s novel and proprietary adeno-associated virus (AAV) viral vectors. Responsibilities will include helping to develop scalable unit operations supporting viral vector purification such as chromatography, filtration and ultrafiltration. Critical to this role is the ability to concisely interpret and summarize data and to be able to effectively communicate results through high quality technical reports and oral presentations.

Primary responsibilities

  • Independently plan and execute studies related to the recovery and purification of AAV from cell harvest through final formulation steps
  • Lead the design of GMP ready purification steps
  • Evaluate the scalability of processes by leading and assisting in pilot scale production
  • Assist in the tech transfer to internal and external manufacturing organizations by generating development reports and providing on-site technical support
  • Present development study results
  • Author technical reports as needed, including CMC sections for regulatory filings

Requirements

  • A strong background in the fundamentals and scale-up of chromatographic and filtration (NFF, TFF) based separations with biologic molecules
  • Experience with development of purification processes for AAV and other viral vectors is highly preferred
  • Ability to work effectively in a cross-functional team
  • Familiarity with executing analytical methods used to support biologics purification process development (e.g. SDS-PAGE, ELISA, HPLC, etc.)
  • Self-motivated and can work independently
  • Strong verbal and written communication skills are integral to this position

Education & Experience

BS (6+ years), MS (3+) or PhD (0+) years of directly related experience. Degree emphasis in Chemical Engineering, Biochemistry, Bioengineering, or related discipline preferred.

Interested candidates should forward a cover letter and resume / CV to careers@homologymedicines.com.