Scientist/Sr. Scientist, AAV Plasmid and Gene Editing Platform Development

Homology Medicines seeks an outstanding Scientist in the Upstream Process Development team to assist in the advancement of viral gene therapy production processes for novel adeno-associated viruses (AAVs). The individual in this role will be a highly-skilled, talented and motivated researcher who will work to develop and characterize next generation plasmids for AAV vectors capable of genome editing. We seek candidates with proven ability to work independently and collaboratively who are driven to pursue cutting edge science and develop next generation therapies to transform the lives of patients.

Essential Functions and Duties

  • Advance technical understanding and development of critical parameters in mammalian cell culture production systems for gene editing AAV vectors
  • Develop and implement upstream operations including cell banking, vector production, virus harvest, and preparation of material for downstream purification
  • Design, development, and characterization of novel plasmids for AAV production using molecular and cell-based assays
  • Analyze vector specific characteristics including packaging efficiency and product quality, as impacted by packaging and ITR plasmid and integrity
  • Collaborate closely with analytical characterization team to evaluate critical vector attributes and process performance parameters for gene editing AAV vector production
  • Lead a team of research associate completing assigned tasks and serve as scientific mentor to overseeing laboratory experimentation and data analysis
  • Author technical reports and tech transfer documents as needed

Skills and Experience

  • BS/MS or equivalent with 10+ years industry experience or PhD with 6+ years industry experience in viral vector production
  • Prior experience characterizing and troubleshooting upstream bioprocessing methods
  • Expertise in molecular cloning techniques preferably with AAV/ITR experience
  • Thorough understanding of virus characterization methods including nucleic acid and protein-based approaches
  • Expertise in the manufacturing of live virus or viral vector product in a high-volume production environment preferred, both suspension and adherent formats
  • Familiarity with lab-scale production platforms including adherent cell systems, bioreactors, and wave bags
  • Adept at conducting routine testing and limited troubleshooting of multiple methods
  • Independently motivated, detail oriented and good problem solving ability
  • Excellent interpersonal written and oral communication skills

Interested candidates should forward a cover letter and Resume / CV to careers@homologymedicines.com